In furtherance of the Administration’s objectives to rapidly and responsibly utilize the immense potential of AI, ISOO has issued ISOO Notice 2026-01 to provide guidance regarding agency handling of classified national security information (classified information) and controlled unclassified information (CUI) with the use of various AI systems and tools. As described in the Notice, in accordance with Presidential direction requiring and encouraging agencies to harness AI’s transformative abilities, it is essential to both leverage this new capability to further our national security and economic competitiveness as well as pair this innovation with clear, responsible guardrails. The Notice’s guidance covers requirements that must be adhered to and considerations for AI systems with respect to classified information and CUI.